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Compound
PGDB_C008149
8 activity records1 related patents
2D structure
Cc1c(F)ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)c1OC(F)FCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 57.1 | nM | - | — | GSPT1 | - | HL-60 | IL323841A | PGDB_A009008 | PGDB_C008149 | PGDB_AS000799 | View |
| Kd | - | = | 28 | nM | - | — | CRBN | CRBN | HEK293 | IL323841A | PGDB_A020755 | PGDB_C008149 | PGDB_AS001216 | View |
| Dmax | - | = | 78.4 | % | Concentration series: 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 1 uM, 3 uM, 10 uM | 72 h | GSPT1 | - | HEK293 | IL323841A | PGDB_A030795 | PGDB_C008149 | PGDB_AS002464 | View |
| IC50 | - | = | 47.8 | nM | - | — | GSPT1 | - | NCI-H1155 | IL323841A | PGDB_A034687 | PGDB_C008149 | PGDB_AS002011 | View |
| DC50 | - | = | 557.1 | nM | - | — | GSPT1 | - | HEK293 | IL323841A | PGDB_A060375 | PGDB_C008149 | PGDB_AS000381 | View |
| IC50 | - | = | 44.6 | nM | - | — | GSPT1 | - | NCI-H1155 | IL323841A | PGDB_A064189 | PGDB_C008149 | PGDB_AS000925 | View |
| EC50 | - | = | 216.8 | nM | - | — | GSPT1 | - | HEK293 | IL323841A | PGDB_A066520 | PGDB_C008149 | PGDB_AS002492 | View |
| IC50 | - | = | 55.2 | nM | - | — | GSPT1 | - | HL-60 | IL323841A | PGDB_A076802 | PGDB_C008149 | PGDB_AS002473 | View |