PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ccc(Cl)cc1N1CCN(Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1

Compound summary

Compound IDPGDB_C019187

FormulaC25H27ClN4O3

Molecular weight466.969

InChIKeyVJUBMQSNPCDHLJ-UHFFFAOYSA-N

Physicochemical properties

Exact mass466.1772

RDKit cLogP2.73

TPSA73

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms33

Hetero atoms8

Rings / aromatic5 / 2

Fraction Csp30.4

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	100-500	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A018522	PGDB_C019187	PGDB_AS000690	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A025713	PGDB_C019187	PGDB_AS000593	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	CCRF-CEM	WO2025016359A1	PGDB_A029586	PGDB_C019187	PGDB_AS000461	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A038792	PGDB_C019187	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A058571	PGDB_C019187	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A059748	PGDB_C019187	PGDB_AS002465	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A063867	PGDB_C019187	PGDB_AS001897	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A065078	PGDB_C019187	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A069617	PGDB_C019187	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A077500	PGDB_C019187	PGDB_AS002547	View

Rows per pagePage 1 of 1 · 10 recordsGo to page