PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCN(c5cccc(Cl)c5Cl)CC4)c(F)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019232

FormulaC24H23Cl2FN4O3

Molecular weight505.377

InChIKeyTUVPKSYQGCAZGR-UHFFFAOYSA-N

Physicochemical properties

Exact mass504.1131

RDKit cLogP3.22

TPSA73

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms34

Hetero atoms10

Rings / aromatic5 / 2

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A019914	PGDB_C019232	PGDB_AS002465	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A032278	PGDB_C019232	PGDB_AS001084	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A048226	PGDB_C019232	PGDB_AS001760	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A053654	PGDB_C019232	PGDB_AS000262	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A059565	PGDB_C019232	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A065542	PGDB_C019232	PGDB_AS002547	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A065745	PGDB_C019232	PGDB_AS000690	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A068021	PGDB_C019232	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A074626	PGDB_C019232	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A076186	PGDB_C019232	PGDB_AS001647	View

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