PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ccc(N2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)s1

Compound summary

Compound IDPGDB_C019248

FormulaC23H26N4O3S

Molecular weight438.553

InChIKeyKRMBHKQEAVYSDZ-UHFFFAOYSA-N

Physicochemical properties

Exact mass438.1726

RDKit cLogP2.14

TPSA73

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms31

Hetero atoms8

Rings / aromatic5 / 2

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A010629	PGDB_C019248	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A018571	PGDB_C019248	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A033895	PGDB_C019248	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A049315	PGDB_C019248	PGDB_AS001647	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A052957	PGDB_C019248	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A062402	PGDB_C019248	PGDB_AS002547	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A064440	PGDB_C019248	PGDB_AS000690	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A070157	PGDB_C019248	PGDB_AS001975	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A074699	PGDB_C019248	PGDB_AS001084	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A075560	PGDB_C019248	PGDB_AS002465	View

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