PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(NN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024195

FormulaC30H27ClFN5O4

Molecular weight576.028

InChIKeyLXKNQWJUYQLTEE-UHFFFAOYSA-N

Physicochemical properties

Exact mass575.1736

RDKit cLogP3.69

TPSA102.1

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms41

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.27

Formal charge0

Fragments1

Activity compounds and values

Activity records

21 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A008336	PGDB_C024195	PGDB_AS001140	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A010537	PGDB_C024195	PGDB_AS000866	View
IC50	-	>	1	nM	-	—	-	-	TMD8	WO2025162225A1	PGDB_A013103	PGDB_C024195	PGDB_AS000863	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A027836	PGDB_C024195	PGDB_AS000857	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A028244	PGDB_C024195	PGDB_AS000160	View
% Inhibition	-	=	80-100	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A030321	PGDB_C024195	PGDB_AS000245	View
% Inhibition	-	=	80-100	%	10 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A034713	PGDB_C024195	PGDB_AS000859	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A035125	PGDB_C024195	PGDB_AS000689	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A035238	PGDB_C024195	PGDB_AS002558	View
IC50	-	>	1	nM	-	—	-	-	MM.1S	WO2025162225A1	PGDB_A040450	PGDB_C024195	PGDB_AS001456	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A044650	PGDB_C024195	PGDB_AS001561	View
% Inhibition	-	=	60-70	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A047123	PGDB_C024195	PGDB_AS001349	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A050933	PGDB_C024195	PGDB_AS001726	View
% Inhibition	-	=	100-105	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A054870	PGDB_C024195	PGDB_AS001155	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A055366	PGDB_C024195	PGDB_AS001812	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A056433	PGDB_C024195	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A057936	PGDB_C024195	PGDB_AS002453	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A058430	PGDB_C024195	PGDB_AS000568	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A064833	PGDB_C024195	PGDB_AS000750	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A076310	PGDB_C024195	PGDB_AS000351	View

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