PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCN(C(c5ccccc5)c5cccnc5)CC4)c(F)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024209

FormulaC29H29FN6O3

Molecular weight528.588

InChIKeyXXGCKXVBYVXEGY-UHFFFAOYSA-N

Physicochemical properties

Exact mass528.2285

RDKit cLogP2.72

TPSA97.9

HBD / HBA2 / 7

Rotatable bonds6

Heavy atoms39

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.31

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	70-80	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A021455	PGDB_C024209	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A022735	PGDB_C024209	PGDB_AS001726	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A027777	PGDB_C024209	PGDB_AS000568	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A032339	PGDB_C024209	PGDB_AS000689	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A034716	PGDB_C024209	PGDB_AS000091	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A043273	PGDB_C024209	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A046186	PGDB_C024209	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A059685	PGDB_C024209	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A067913	PGDB_C024209	PGDB_AS002453	View
% Inhibition	-	=	20-30	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A076894	PGDB_C024209	PGDB_AS001349	View

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