PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC1(C)CC(c2ccc(Cl)cc2)=C(CN2CC3CN(Nc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3C2)CO1

Compound summary

Compound IDPGDB_C024359

FormulaC33H38ClN5O4

Molecular weight604.151

InChIKeyJCZJODDMGGWEOA-UHFFFAOYSA-N

Physicochemical properties

Exact mass603.2612

RDKit cLogP3.94

TPSA94.2

HBD / HBA2 / 7

Rotatable bonds6

Heavy atoms43

Hetero atoms10

Rings / aromatic7 / 2

Fraction Csp30.48

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A017230	PGDB_C024359	PGDB_AS001140	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A026882	PGDB_C024359	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A033741	PGDB_C024359	PGDB_AS002453	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A034084	PGDB_C024359	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A039644	PGDB_C024359	PGDB_AS000351	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A047450	PGDB_C024359	PGDB_AS002133	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A049879	PGDB_C024359	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A065717	PGDB_C024359	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A071480	PGDB_C024359	PGDB_AS000750	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A076514	PGDB_C024359	PGDB_AS000866	View

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