PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN117836288A

AssigneePlexium

TitleAryl compounds and pharmaceutical compositions that modulate IKZF2

Family ID90504459

Family members1

Filing year2022

Publication date2024-03-01

JurisdictionCN

Compounds95

Activity records239

Assays7

Activity compounds and values

Activity records

239 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
EC50	-	>	10	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A006999	PGDB_C000438	PGDB_AS001696	View
EC50	-	=	0.031	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A007205	PGDB_C000391	PGDB_AS001696	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	PGDB_A007308	PGDB_C000401	PGDB_AS001378	View
EC50	-	=	0.015	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A007493	PGDB_C000409	PGDB_AS001696	View
EC50	-	=	0.025	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A007929	PGDB_C000392	PGDB_AS001696	View
EC50	-	=	0.052	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A008113	PGDB_C000414	PGDB_AS001696	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	PGDB_A008144	PGDB_C000458	PGDB_AS002458	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	PGDB_A008685	PGDB_C000394	PGDB_AS002458	View
EC50	-	=	0.006	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A008719	PGDB_C000462	PGDB_AS001696	View
DC50	-	=	0.006	uM	-	—	IKZF2	-	HEK293T	PGDB_A009549	PGDB_C000381	PGDB_AS002115	View
EC50	-	=	0.089	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A010815	PGDB_C000403	PGDB_AS001696	View
EC50	-	=	0.017	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A010905	PGDB_C000415	PGDB_AS001696	View
EC50	-	>	10	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A011255	PGDB_C000424	PGDB_AS001696	View
EC50	-	=	0.025	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A011391	PGDB_C000392	PGDB_AS001696	View
% Degradation	-	=	37.8	%	1 uM	24 h	IKZF2	CRBN	HEK293T	PGDB_A011827	PGDB_C000415	PGDB_AS002458	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	PGDB_A011997	PGDB_C000414	PGDB_AS001378	View
EC50	-	=	0.052	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A012004	PGDB_C000393	PGDB_AS001696	View
EC50	-	>	10	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A012352	PGDB_C000440	PGDB_AS001696	View
% Degradation	-	=	79.2	%	1 uM	24 h	IKZF2	-	HEK293T	PGDB_A012642	PGDB_C000387	PGDB_AS002485	View
EC50	-	=	0.015	uM	-	—	CRBN	CRBN	HEK293T	PGDB_A013227	PGDB_C000412	PGDB_AS001696	View

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