PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(O[C@H]4CCCC[C@@H]4N4CC(c5ccccc5)C4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000414

FormulaC28H30FN3O4

Molecular weight491.563

InChIKeyRIQVFCDNSXZUJO-LIMDNCRJSA-N

Physicochemical properties

Exact mass491.222

RDKit cLogP3.38

TPSA79

HBD / HBA1 / 5

Rotatable bonds5

Heavy atoms36

Hetero atoms8

Rings / aromatic6 / 2

Fraction Csp30.46

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
EC50	-	=	0.052	uM	-	—	CRBN	CRBN	HEK293T	CN117836288A	PGDB_A008113	PGDB_C000414	PGDB_AS001696	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	CN117836288A	PGDB_A011997	PGDB_C000414	PGDB_AS001378	View
EC50	-	=	0.024	uM	-	—	CRBN	CRBN	-	US20230265071A1	PGDB_A013098	PGDB_C000414	PGDB_AS001482	View
% Degradation	-	=	74.8	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A013562	PGDB_C000414	PGDB_AS002458	View
% Degradation	-	=	75.1	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A014561	PGDB_C000414	PGDB_AS002458	View
% Degradation	-	=	74.8	%	1 uM	24 h	IKZF2	-	HEK293T	US20230265071A1	PGDB_A029639	PGDB_C000414	PGDB_AS000278	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	US20230265071A1	PGDB_A036836	PGDB_C000414	PGDB_AS000322	View
EC50	-	=	0.052	uM	-	—	CRBN	CRBN	-	US20230265071A1	PGDB_A037456	PGDB_C000414	PGDB_AS001482	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	CN117836288A	PGDB_A046375	PGDB_C000414	PGDB_AS001378	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	AR126418A1	PGDB_A046966	PGDB_C000414	PGDB_AS002212	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	US20230265071A1	PGDB_A050116	PGDB_C000414	PGDB_AS000322	View
% Degradation	-	=	75.1	%	1 uM	24 h	IKZF2	-	HEK293T	US20230265071A1	PGDB_A055649	PGDB_C000414	PGDB_AS000278	View
% Degradation	-	=	75.1	%	1 uM	24 h	IKZF2	CRBN	HEK293T	AR126418A1	PGDB_A060809	PGDB_C000414	PGDB_AS000416	View
EC50	-	=	0.024	uM	-	—	CRBN	CRBN	HEK293T	CN117836288A	PGDB_A070260	PGDB_C000414	PGDB_AS001696	View
EC50	-	=	0.052	uM	-	—	IKZF2	CRBN	HEK293T	AR126418A1	PGDB_A076118	PGDB_C000414	PGDB_AS001328	View

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