PatGlueDB | Molecular Glue Patent Bioactivity Database

Assay context summary

Assay context

81 activity records

Assay family% Degradation

Systemcell_based

Readout% Degradation

TargetIKZF2

E3CRBN

Cell lineHEK293T

Detection targetprotein_degradation

Activity compounds and values

Activity records

81 records

Metric	Control	Relation	Value	Unit	Concentration	Time	Target	E3	Cell line	Patent	Record ID	Compound	Assay	Details
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A008144	PGDB_C000458	PGDB_AS002458	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A008685	PGDB_C000394	PGDB_AS002458	View
% Degradation	-	=	37.8	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A011827	PGDB_C000415	PGDB_AS002458	View
% Degradation	-	=	74.8	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A013562	PGDB_C000414	PGDB_AS002458	View
% Degradation	-	=	75.1	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A014561	PGDB_C000414	PGDB_AS002458	View
% Degradation	-	=	63.6	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A015365	PGDB_C000421	PGDB_AS002458	View
% Degradation	-	=	78.9	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A017710	PGDB_C000399	PGDB_AS002458	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A018391	PGDB_C000405	PGDB_AS002458	View
% Degradation	-	=	82.3	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A018804	PGDB_C000391	PGDB_AS002458	View
% Degradation	-	=	77.9	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A018984	PGDB_C000466	PGDB_AS002458	View
% Degradation	-	=	76.3	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A019014	PGDB_C000413	PGDB_AS002458	View
% Degradation	-	=	70.2	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A019923	PGDB_C000463	PGDB_AS002458	View
% Degradation	-	=	90.5	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A020468	PGDB_C000402	PGDB_AS002458	View
% Degradation	-	=	44.9	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A022197	PGDB_C000412	PGDB_AS002458	View
% Degradation	-	=	36.8	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A022590	PGDB_C000422	PGDB_AS002458	View
% Degradation	-	=	77.2	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A023311	PGDB_C000470	PGDB_AS002458	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A023343	PGDB_C000396	PGDB_AS002458	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A024673	PGDB_C000398	PGDB_AS002458	View
% Degradation	-	=	84.6	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A026844	PGDB_C000393	PGDB_AS002458	View
% Degradation	-	=	74.4	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A028403	PGDB_C000401	PGDB_AS002458	View

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