PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

N#Cc1cc(Cl)ccc1C1CN([C@@H]2CCCC[C@@H]2Oc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1

Compound summary

Compound IDPGDB_C000392

FormulaC29H29ClN4O4

Molecular weight533.028

InChIKeyKOLPLYWGRIIREE-ITNFAHLUSA-N

Physicochemical properties

Exact mass532.1877

RDKit cLogP3.76

TPSA102.7

HBD / HBA1 / 6

Rotatable bonds5

Heavy atoms38

Hetero atoms9

Rings / aromatic6 / 2

Fraction Csp30.45

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
EC50	-	=	0.025	uM	-	—	CRBN	CRBN	HEK293T	CN117836288A	PGDB_A007929	PGDB_C000392	PGDB_AS001696	View
EC50	-	=	0.025	uM	-	—	CRBN	CRBN	HEK293T	CN117836288A	PGDB_A011391	PGDB_C000392	PGDB_AS001696	View
EC50	-	=	0.025	uM	-	—	CRBN	CRBN	-	US20230265071A1	PGDB_A014929	PGDB_C000392	PGDB_AS001482	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	CN117836288A	PGDB_A017118	PGDB_C000392	PGDB_AS001378	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	US20230265071A1	PGDB_A018789	PGDB_C000392	PGDB_AS000322	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	-	HEK293T	US20230265071A1	PGDB_A027738	PGDB_C000392	PGDB_AS000278	View
EC50	-	=	0.025	uM	-	—	CRBN	CRBN	-	US20230265071A1	PGDB_A042192	PGDB_C000392	PGDB_AS001482	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	AR126418A1	PGDB_A046373	PGDB_C000392	PGDB_AS000416	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A049278	PGDB_C000392	PGDB_AS002458	View
EC50	-	=	0.025	uM	-	—	IKZF2	CRBN	HEK293T	AR126418A1	PGDB_A054146	PGDB_C000392	PGDB_AS001328	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A058758	PGDB_C000392	PGDB_AS002458	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	AR126418A1	PGDB_A060032	PGDB_C000392	PGDB_AS000416	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	-	HEK293T	US20230265071A1	PGDB_A071090	PGDB_C000392	PGDB_AS000278	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	AR126418A1	PGDB_A074164	PGDB_C000392	PGDB_AS002212	View
EC50	-	=	0.025	uM	-	—	IKZF2	CRBN	HEK293T	AR126418A1	PGDB_A075206	PGDB_C000392	PGDB_AS001328	View

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