PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN121108130A

AssigneeShanghai Institute Of Materia Medica Of Cas, Zhongke Zhongshan Pharmaceutical Innovation Research Institute

TitleA CDK degrading agent, its preparation method and application

Family ID97938573

Family members1

Filing year2024

Publication date2025-12-12

JurisdictionCN

Compounds12

Activity records36

Assays3

Activity compounds and values

Activity records

36 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	30.35	nM	-	—	CDK12	-	MDA-MB-231	PGDB_A008061	PGDB_C007331	PGDB_AS001069	View
IC50	-	=	19.37	nM	-	—	CDK12	-	-	PGDB_A008223	PGDB_C007326	PGDB_AS002060	View
IC50	-	=	57.46	nM	-	—	CDK12	-	-	PGDB_A008550	PGDB_C007335	PGDB_AS002060	View
IC50	-	>	10000	nM	-	—	CDK12	-	MDA-MB-468	PGDB_A009020	PGDB_C007327	PGDB_AS000556	View
IC50	-	=	31.52	nM	-	—	CDK12	-	-	PGDB_A010946	PGDB_C007328	PGDB_AS002060	View
IC50	-	=	20.28	nM	-	—	CDK12	-	MDA-MB-468	PGDB_A012172	PGDB_C007164	PGDB_AS000556	View
IC50	-	=	2861	nM	-	—	CDK12	-	MDA-MB-231	PGDB_A013315	PGDB_C007327	PGDB_AS001069	View
IC50	-	=	10.11	nM	-	—	CDK12	-	MDA-MB-468	PGDB_A019437	PGDB_C007325	PGDB_AS000556	View
IC50	-	=	13.5	nM	-	—	CDK12	-	MDA-MB-468	PGDB_A020953	PGDB_C007331	PGDB_AS000556	View
IC50	-	>	10000	nM	-	—	CDK12	-	-	PGDB_A022810	PGDB_C007333	PGDB_AS002060	View
IC50	-	=	34.54	nM	-	—	CDK12	-	-	PGDB_A028513	PGDB_C007325	PGDB_AS002060	View
IC50	-	=	351.6	nM	-	—	CDK12	-	MDA-MB-231	PGDB_A031323	PGDB_C007329	PGDB_AS001069	View
IC50	-	=	17.51	nM	-	—	CDK12	-	-	PGDB_A031523	PGDB_C007331	PGDB_AS002060	View
IC50	-	=	219	nM	-	—	CDK12	-	MDA-MB-231	PGDB_A033466	PGDB_C007335	PGDB_AS001069	View
IC50	-	=	2925	nM	-	—	CDK12	-	MDA-MB-231	PGDB_A035112	PGDB_C007333	PGDB_AS001069	View
IC50	-	=	36.24	nM	-	—	CDK12	-	MDA-MB-468	PGDB_A036721	PGDB_C007330	PGDB_AS000556	View
IC50	-	=	46.44	nM	-	—	CDK12	-	MDA-MB-231	PGDB_A040486	PGDB_C007326	PGDB_AS001069	View
IC50	-	=	353.7	nM	-	—	CDK12	-	MDA-MB-468	PGDB_A044111	PGDB_C007335	PGDB_AS000556	View
IC50	-	>	10000	nM	-	—	CDK12	-	MDA-MB-468	PGDB_A048055	PGDB_C007333	PGDB_AS000556	View
IC50	-	=	196.5	nM	-	—	CDK12	-	MDA-MB-468	PGDB_A050347	PGDB_C007332	PGDB_AS000556	View

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