PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025224249A1

AssigneeMonte Rosa Therapeutics

TitleCompounds that mediate protein degradation and methods of use thereof

Family ID95558887

Family members1

Filing year2025

Publication date2025-10-30

JurisdictionWO

Compounds82

Activity records246

Assays3

Activity compounds and values

Activity records

246 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	=	47.5	%	-	24 h	CDK2	-	HEK293	PGDB_A007358	PGDB_C011745	PGDB_AS002358	View
Dmax	-	=	-0.1	%	-	24 h	GSPT1	-	HEK293	PGDB_A007405	PGDB_C011702	PGDB_AS001257	View
Dmax	-	=	61.9	%	-	24 h	CDK2	-	HEK293	PGDB_A007551	PGDB_C011755	PGDB_AS002358	View
DC50	-	=	219.2	nM	-	—	CDK2	-	HEK293	PGDB_A008386	PGDB_C011710	PGDB_AS000391	View
Dmax	-	=	10.1	%	-	24 h	GSPT1	-	HEK293	PGDB_A008766	PGDB_C011719	PGDB_AS001257	View
Dmax	-	=	6.2	%	-	24 h	GSPT1	-	HEK293	PGDB_A009045	PGDB_C011729	PGDB_AS001257	View
Dmax	-	=	31.5	%	-	24 h	GSPT1	-	HEK293	PGDB_A009353	PGDB_C011750	PGDB_AS001257	View
Dmax	-	=	54.5	%	-	24 h	CDK2	-	HEK293	PGDB_A011066	PGDB_C011752	PGDB_AS002358	View
DC50	-	=	24.6	nM	-	—	CDK2	-	HEK293	PGDB_A011084	PGDB_C011749	PGDB_AS000391	View
Dmax	-	=	10.5	%	-	24 h	GSPT1	-	HEK293	PGDB_A011478	PGDB_C011766	PGDB_AS001257	View
Dmax	-	=	11.2	%	-	24 h	GSPT1	-	HEK293	PGDB_A011636	PGDB_C011751	PGDB_AS001257	View
Dmax	-	=	51.7	%	-	24 h	CDK2	-	HEK293	PGDB_A011904	PGDB_C011761	PGDB_AS002358	View
Dmax	-	=	53.3	%	-	24 h	CDK2	-	HEK293	PGDB_A012911	PGDB_C011704	PGDB_AS002358	View
Dmax	-	=	1.2	%	-	24 h	GSPT1	-	HEK293	PGDB_A013425	PGDB_C011696	PGDB_AS001257	View
DC50	-	=	958.9	nM	-	—	CDK2	-	HEK293	PGDB_A013758	PGDB_C011743	PGDB_AS000391	View
DC50	-	=	154.6	nM	-	—	CDK2	-	HEK293	PGDB_A014581	PGDB_C011705	PGDB_AS000391	View
DC50	-	=	277.2	nM	-	—	CDK2	-	HEK293	PGDB_A014612	PGDB_C011715	PGDB_AS000391	View
Dmax	-	=	9.1	%	-	24 h	GSPT1	-	HEK293	PGDB_A015026	PGDB_C011703	PGDB_AS001257	View
Dmax	-	=	3.1	%	-	24 h	GSPT1	-	HEK293	PGDB_A015233	PGDB_C011739	PGDB_AS001257	View
Dmax	-	=	4.8	%	-	24 h	GSPT1	-	HEK293	PGDB_A015268	PGDB_C011772	PGDB_AS001257	View

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