PatGlueDB | Molecular Glue Patent Bioactivity Database

Target summary

Target IDPGDB_T000100

NameCRBN

Gene symbolCRBN

Protein nameProtein cereblon

UniProt IDQ96SW2

RoleE3_ligase | assay_marker

Compounds3,940

Activity records5,549

Assays89

Patents59

Activity compounds and values

Activity records

5,549 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
EC50	-	=	1.2	uM	-	—	CRBN	CRBN	-	WO2026099466A1	PGDB_A000010	PGDB_C031256	PGDB_AS002171	View
EC50	-	=	2.7	uM	-	—	CRBN	CRBN	-	WO2026099466A1	PGDB_A000019	PGDB_C031289	PGDB_AS002171	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000021	PGDB_C030500	PGDB_AS000662	View
% Inhibition	-	=	20-30	%	0.5 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000024	PGDB_C030285	PGDB_AS000662	View
% Inhibition	-	=	10-20	%	0.5 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000084	PGDB_C030485	PGDB_AS000662	View
% Inhibition	-	=	70-80	%	2 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000095	PGDB_C030393	PGDB_AS001031	View
EC50	-	=	1.7	uM	-	—	CRBN	CRBN	-	WO2026099466A1	PGDB_A000151	PGDB_C031302	PGDB_AS002171	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000164	PGDB_C030542	PGDB_AS000662	View
% Inhibition	-	=	60-70	%	2 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000217	PGDB_C030490	PGDB_AS001031	View
EC50	-	=	1.8	uM	-	—	CRBN	CRBN	-	WO2026099466A1	PGDB_A000219	PGDB_C031326	PGDB_AS002171	View
EC50	-	=	3.3	uM	-	—	CRBN	CRBN	-	WO2026099466A1	PGDB_A000235	PGDB_C031225	PGDB_AS002171	View
IC50	-	=	138	nM	-	—	CRBN	CRBN	Tni(Hi5)insect	WO2026114958A1	PGDB_A000239	PGDB_C031957	PGDB_AS000132	View
EC50	-	=	1.2	uM	-	—	CRBN	CRBN	-	WO2026099466A1	PGDB_A000242	PGDB_C031292	PGDB_AS002171	View
% Inhibition	-	=	90-100	%	2 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000256	PGDB_C030430	PGDB_AS001031	View
% Inhibition	-	=	30-40	%	0.5 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000285	PGDB_C030463	PGDB_AS000662	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000304	PGDB_C030445	PGDB_AS000662	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000313	PGDB_C030455	PGDB_AS000662	View
% Inhibition	-	=	80-90	%	2 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000329	PGDB_C030481	PGDB_AS001031	View
EC50	-	=	1.9	uM	-	—	CRBN	CRBN	-	WO2026099466A1	PGDB_A000352	PGDB_C031299	PGDB_AS002171	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A000354	PGDB_C030372	PGDB_AS000662	View

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