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Compound
PGDB_C002501
10 activity records1 related patents
2D structure
CC1(C)CCC(CN2CCN(Cc3cc4c(cc3F)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C(c2ccc(F)cc2)C1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | <= | 5 | nM | - | — | - | - | CCRF-CEM | WO2024032689A1 | PGDB_A007682 | PGDB_C002501 | PGDB_AS001396 | View |
| IC50 | - | <= | 5 | nM | - | — | - | - | MV-4-11 | WO2024032689A1 | PGDB_A012508 | PGDB_C002501 | PGDB_AS000885 | View |
| IC50 | - | = | 5-10 | nM | - | — | - | - | MM.1S | WO2024032689A1 | PGDB_A019876 | PGDB_C002501 | PGDB_AS001703 | View |
| % Degradation | - | > | 50 | % | Concentration context: 500 nM | 24 h | IKZF3 | - | - | WO2024032689A1 | PGDB_A022910 | PGDB_C002501 | PGDB_AS000176 | View |
| % Degradation | - | > | 50 | % | Concentration context: 500 nM | 24 h | GSPT1 | - | - | WO2024032689A1 | PGDB_A023783 | PGDB_C002501 | PGDB_AS000668 | View |
| IC50 | - | = | 5-10 | nM | - | — | - | - | Mino | WO2024032689A1 | PGDB_A028822 | PGDB_C002501 | PGDB_AS001319 | View |
| IC50 | - | = | 10-50 | nM | - | — | - | - | Kasumi-1 | WO2024032689A1 | PGDB_A030829 | PGDB_C002501 | PGDB_AS001291 | View |
| % Degradation | - | > | 50 | % | Concentration context: 500 nM | 24 h | IKZF1 | - | - | WO2024032689A1 | PGDB_A045165 | PGDB_C002501 | PGDB_AS002239 | View |
| IC50 | - | = | 10-50 | nM | - | — | - | - | Daudi | WO2024032689A1 | PGDB_A061312 | PGDB_C002501 | PGDB_AS002481 | View |
| IC50 | - | = | 0.57 | uM | - | — | CRBN | CRBN | - | WO2024032689A1 | PGDB_A061474 | PGDB_C002501 | PGDB_AS000095 | View |