PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC(=O)N1CCC[C@H]1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O

Compound summary

Compound IDPGDB_C002847

FormulaC20H22N4O5

Molecular weight398.419

InChIKeyORQJRRLFDQWUMY-VYRBHSGPSA-N

Physicochemical properties

Exact mass398.159

RDKit cLogP0.4

TPSA115.9

HBD / HBA2 / 5

Rotatable bonds3

Heavy atoms29

Hetero atoms9

Rings / aromatic4 / 1

Fraction Csp30.45

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	40.3	%	-	-	CSNK1A1	-	-	WO2024059107A1	PGDB_A008277	PGDB_C002847	PGDB_AS002567	View
Dmax	-	=	8.3	%	-	72 h	IKZF1	-	NCI-H1155	WO2024059107A1	PGDB_A012651	PGDB_C002847	PGDB_AS002425	View
% Degradation	-	=	21.4	%	100 nM	-	IKZF2	-	-	WO2024059107A1	PGDB_A014216	PGDB_C002847	PGDB_AS001414	View
DC50	-	=	502.9	nM	-	—	CSNK1A1	-	NCI-H1155	WO2024059107A1	PGDB_A026240	PGDB_C002847	PGDB_AS002387	View
% Degradation	-	=	9.2	%	100 nM	-	CSNK1A1	-	-	WO2024059107A1	PGDB_A027621	PGDB_C002847	PGDB_AS000209	View
% Degradation	-	=	10.1	%	1 uM	-	GSPT1	-	-	WO2024059107A1	PGDB_A029160	PGDB_C002847	PGDB_AS001974	View
% Degradation	-	=	57	%	1 uM	-	IKZF2	-	-	WO2024059107A1	PGDB_A033181	PGDB_C002847	PGDB_AS000892	View
Dmax	-	=	79.5	%	-	72 h	IKZF2	-	NCI-H1155	WO2024059107A1	PGDB_A046493	PGDB_C002847	PGDB_AS000259	View
% Degradation	-	=	5	%	1 uM	-	IKZF1	-	-	WO2024059107A1	PGDB_A046864	PGDB_C002847	PGDB_AS000768	View
% Degradation	-	=	8.6	%	100 nM	-	GSPT1	-	-	WO2024059107A1	PGDB_A046888	PGDB_C002847	PGDB_AS002431	View
% Degradation	-	=	3.6	%	100 nM	-	IKZF1	-	-	WO2024059107A1	PGDB_A048376	PGDB_C002847	PGDB_AS000707	View
Dmax	-	=	14.2	%	-	72 h	GSPT1	-	NCI-H1155	WO2024059107A1	PGDB_A051731	PGDB_C002847	PGDB_AS001612	View
% Degradation	-	=	26.3	%	1 uM	-	CSNK1A1	-	-	WO2024059107A1	PGDB_A063259	PGDB_C002847	PGDB_AS000685	View
DC50	-	=	339.7	nM	-	—	IKZF2	-	NCI-H1155	WO2024059107A1	PGDB_A071184	PGDB_C002847	PGDB_AS002270	View

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