PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2024059107A1

AssigneeHarvard University

TitleIkzf2 and ck1-alpha degrading compounds and uses thereof

Family ID90275746

Family members2

Filing year2023

Publication date2024-03-21

JurisdictionWO

Compounds44

Activity records398

Assays16

Activity compounds and values

Activity records

398 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	67.4	%	1 uM	-	CSNK1A1	-	-	PGDB_A007173	PGDB_C002810	PGDB_AS000685	View
% Degradation	-	=	4.4	%	100 nM	-	IKZF1	-	-	PGDB_A007445	PGDB_C002807	PGDB_AS000707	View
% Degradation	-	=	24	%	1 uM	-	IKZF1	-	-	PGDB_A007660	PGDB_C002831	PGDB_AS000768	View
% Degradation	-	=	6.1	%	100 nM	-	GSPT1	-	-	PGDB_A008001	PGDB_C002837	PGDB_AS002431	View
% Degradation	-	=	7	%	1 uM	-	IKZF1	-	-	PGDB_A008146	PGDB_C002828	PGDB_AS000768	View
% Degradation	-	=	55.4	%	1 uM	-	CSNK1A1	-	-	PGDB_A008181	PGDB_C002813	PGDB_AS000685	View
% Degradation	-	=	9.3	%	100 nM	-	IKZF1	-	-	PGDB_A008209	PGDB_C002813	PGDB_AS000707	View
Dmax	-	=	40.3	%	-	-	CSNK1A1	-	-	PGDB_A008277	PGDB_C002847	PGDB_AS002567	View
% Degradation	-	=	12.5	%	100 nM	-	GSPT1	-	-	PGDB_A008406	PGDB_C002826	PGDB_AS002431	View
Dmax	-	=	92.8	%	-	72 h	IKZF2	-	NCI-H1155	PGDB_A008488	PGDB_C002845	PGDB_AS000259	View
% Degradation	-	=	70.8	%	100 nM	-	IKZF2	-	-	PGDB_A008495	PGDB_C002817	PGDB_AS001414	View
DC50	-	=	72	nM	-	—	IKZF1	-	NCI-H1155	PGDB_A008514	PGDB_C002849	PGDB_AS001115	View
% Degradation	-	=	75	%	100 nM	-	IKZF2	-	-	PGDB_A008953	PGDB_C002834	PGDB_AS001414	View
% Degradation	-	=	50.2	%	100 nM	-	CSNK1A1	-	-	PGDB_A009085	PGDB_C002819	PGDB_AS000209	View
% Degradation	-	=	9.2	%	100 nM	-	GSPT1	-	-	PGDB_A009147	PGDB_C002834	PGDB_AS002431	View
% Degradation	-	=	76.2	%	100 nM	-	CSNK1A1	-	-	PGDB_A009175	PGDB_C002843	PGDB_AS000209	View
% Degradation	-	=	91.8	%	1 uM	-	IKZF2	-	-	PGDB_A009399	PGDB_C002838	PGDB_AS000892	View
% Degradation	-	=	48.1	%	100 nM	-	CSNK1A1	-	-	PGDB_A009504	PGDB_C002828	PGDB_AS000209	View
% Degradation	-	=	69.9	%	1 uM	-	CSNK1A1	-	-	PGDB_A009809	PGDB_C002829	PGDB_AS000685	View
% Degradation	-	=	51.3	%	100 nM	-	CSNK1A1	-	-	PGDB_A010007	PGDB_C002845	PGDB_AS000209	View

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