PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CN1C(=O)CCc2cc(C(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)ccc21

Compound summary

Compound IDPGDB_C002848

FormulaC24H22N4O5

Molecular weight446.463

InChIKeyYQWHBPBHDFSMCP-UHFFFAOYSA-N

Physicochemical properties

Exact mass446.159

RDKit cLogP1.61

TPSA115.9

HBD / HBA2 / 5

Rotatable bonds3

Heavy atoms33

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	4.1	%	1 uM	-	IKZF1	-	-	WO2024059107A1	PGDB_A030113	PGDB_C002848	PGDB_AS000768	View
% Degradation	-	=	60.1	%	100 nM	-	CSNK1A1	-	-	WO2024059107A1	PGDB_A032187	PGDB_C002848	PGDB_AS000209	View
DC50	-	=	83.1	nM	-	—	IKZF2	-	NCI-H1155	WO2024059107A1	PGDB_A032645	PGDB_C002848	PGDB_AS002270	View
Dmax	-	=	13.1	%	-	72 h	IKZF1	-	NCI-H1155	WO2024059107A1	PGDB_A033412	PGDB_C002848	PGDB_AS002425	View
Dmax	-	=	78	%	-	-	CSNK1A1	-	-	WO2024059107A1	PGDB_A035000	PGDB_C002848	PGDB_AS002567	View
% Degradation	-	=	1.6	%	100 nM	-	GSPT1	-	-	WO2024059107A1	PGDB_A036440	PGDB_C002848	PGDB_AS002431	View
% Degradation	-	=	74.1	%	1 uM	-	CSNK1A1	-	-	WO2024059107A1	PGDB_A041738	PGDB_C002848	PGDB_AS000685	View
% Degradation	-	=	-3.4	%	1 uM	-	GSPT1	-	-	WO2024059107A1	PGDB_A042657	PGDB_C002848	PGDB_AS001974	View
% Degradation	-	=	2.4	%	100 nM	-	IKZF1	-	-	WO2024059107A1	PGDB_A055881	PGDB_C002848	PGDB_AS000707	View
% Degradation	-	=	52.6	%	100 nM	-	IKZF2	-	-	WO2024059107A1	PGDB_A056692	PGDB_C002848	PGDB_AS001414	View
Dmax	-	=	95.9	%	-	72 h	IKZF2	-	NCI-H1155	WO2024059107A1	PGDB_A062058	PGDB_C002848	PGDB_AS000259	View
% Degradation	-	=	87.1	%	1 uM	-	IKZF2	-	-	WO2024059107A1	PGDB_A064919	PGDB_C002848	PGDB_AS000892	View
DC50	-	=	32	nM	-	—	CSNK1A1	-	NCI-H1155	WO2024059107A1	PGDB_A069710	PGDB_C002848	PGDB_AS002387	View
Dmax	-	=	5.6	%	-	72 h	GSPT1	-	NCI-H1155	WO2024059107A1	PGDB_A072222	PGDB_C002848	PGDB_AS001612	View

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