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Compound
PGDB_C006597
5 activity records1 related patents
2D structure
O[C@H]1CNCC[C@@H]1CNc1cc(NCc2cn3c(C4CC4)cccc3n2)n2ncc(C3CC3)c2n1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 75 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A030407 | PGDB_C006597 | PGDB_AS001268 | View |
| IC50 | - | = | 8.7 | nM | - | — | CDK12 | - | A673 | CN114929708B | PGDB_A052626 | PGDB_C006597 | PGDB_AS002570 | View |
| IC50 | - | = | 274 | nM | - | — | CDK7 | - | - | CN114929708B | PGDB_A057550 | PGDB_C006597 | PGDB_AS002150 | View |
| IC50 | - | = | 75 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A065659 | PGDB_C006597 | PGDB_AS001187 | View |
| Selectivity index | CDK7 / CDK12 | = | 3.7 | fold | - | — | - | - | - | CN114929708B | PGDB_A071262 | PGDB_C006597 | PGDB_AS002236 | View |