Loading compound
Loading detail record from the SQLite release...
Compound
PGDB_C008016
5 activity records1 related patents
2D structure
CN1Cc2cccc(COC(=O)NCc3cc(Cl)c4c(c3F)C(=O)N(C3CCC(=O)NC3=O)C4)c2C1=OCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kd | - | = | 0.15 | uM | - | — | CRBN | CRBN | - | WO2025043225 | PGDB_A009850 | PGDB_C008016 | PGDB_AS000368 | View |
| Dmax | - | = | 76 | % | 10 uM | 6 h | CDK2 | - | HEK293 | WO2025043225 | PGDB_A021741 | PGDB_C008016 | PGDB_AS000677 | View |
| Dmax | - | = | 5.4 | % | 10 uM | 6 h | GSPT1 | - | HEK293 | WO2025043225 | PGDB_A044966 | PGDB_C008016 | PGDB_AS000429 | View |
| IC50 | - | = | 1 | uM | - | — | GSPT1 | - | HEK293 | WO2025043225 | PGDB_A073107 | PGDB_C008016 | PGDB_AS002511 | View |
| IC50 | - | = | 0.028 | uM | - | — | CDK2 | - | HEK293 | WO2025043225 | PGDB_A074903 | PGDB_C008016 | PGDB_AS001302 | View |