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Compound
PGDB_C008018
5 activity records1 related patents
2D structure
O=C1CCC(N2Cc3c(Cl)cc(CNC(=O)OCc4cc5n(n4)CCN(C4CCC4)C5)c(F)c3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 1 | uM | - | — | GSPT1 | - | HEK293 | WO2025043225 | PGDB_A015244 | PGDB_C008018 | PGDB_AS002511 | View |
| IC50 | - | = | 0.14 | uM | - | — | CDK2 | - | HEK293 | WO2025043225 | PGDB_A038476 | PGDB_C008018 | PGDB_AS001302 | View |
| Dmax | - | = | 4.8 | % | 10 uM | 6 h | GSPT1 | - | HEK293 | WO2025043225 | PGDB_A049317 | PGDB_C008018 | PGDB_AS000429 | View |
| Kd | - | = | 0.24 | uM | - | — | CRBN | CRBN | - | WO2025043225 | PGDB_A052940 | PGDB_C008018 | PGDB_AS000368 | View |
| Dmax | - | = | 53 | % | 10 uM | 6 h | CDK2 | - | HEK293 | WO2025043225 | PGDB_A072530 | PGDB_C008018 | PGDB_AS000677 | View |