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Compound
PGDB_C008152
8 activity records1 related patents
2D structure
Cc1cccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)c1OC(F)FCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kd | - | = | 7.3 | nM | - | — | CRBN | CRBN | HEK293 | IL323841A | PGDB_A010767 | PGDB_C008152 | PGDB_AS001216 | View |
| IC50 | - | = | 33.6 | nM | - | — | GSPT1 | - | HL-60 | IL323841A | PGDB_A011134 | PGDB_C008152 | PGDB_AS000799 | View |
| EC50 | - | = | 128.4 | nM | - | — | GSPT1 | - | HEK293 | IL323841A | PGDB_A026071 | PGDB_C008152 | PGDB_AS002492 | View |
| IC50 | - | = | 32.5 | nM | - | — | GSPT1 | - | HL-60 | IL323841A | PGDB_A036739 | PGDB_C008152 | PGDB_AS002473 | View |
| DC50 | - | = | 495.8 | nM | - | — | GSPT1 | - | HEK293 | IL323841A | PGDB_A038633 | PGDB_C008152 | PGDB_AS000381 | View |
| Dmax | - | = | 73.3 | % | Concentration series: 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 1 uM, 3 uM, 10 uM | 72 h | GSPT1 | - | HEK293 | IL323841A | PGDB_A041799 | PGDB_C008152 | PGDB_AS002464 | View |
| IC50 | - | = | 34.5 | nM | - | — | GSPT1 | - | NCI-H1155 | IL323841A | PGDB_A070685 | PGDB_C008152 | PGDB_AS000925 | View |
| IC50 | - | = | 43.1 | nM | - | — | GSPT1 | - | NCI-H1155 | IL323841A | PGDB_A070782 | PGDB_C008152 | PGDB_AS002011 | View |