PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C4CCN(Cc5ccccc5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C008705

FormulaC25H27N3O3

Molecular weight417.509

InChIKeyOMISHRJQMYQPMG-UHFFFAOYSA-N

Physicochemical properties

Exact mass417.2052

RDKit cLogP2.83

TPSA69.7

HBD / HBA1 / 4

Rotatable bonds4

Heavy atoms31

Hetero atoms6

Rings / aromatic5 / 2

Fraction Csp30.4

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	82	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A014878	PGDB_C008705	PGDB_AS000211	View
Dmax	-	=	63	%	-	24 h	SALL4	-	HEK293	JP2026020265A	PGDB_A020652	PGDB_C008705	PGDB_AS002183	View
EC50	-	=	0.009	uM	-	—	-	-	293GT	CN111051298A	PGDB_A020658	PGDB_C008705	PGDB_AS001169	View
EC50	-	=	0.012	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A023645	PGDB_C008705	PGDB_AS001535	View
Dmax	-	=	82	%	-	24 h	IKZF2	-	-	JP2026020265A	PGDB_A026607	PGDB_C008705	PGDB_AS002581	View
% Degradation	-	=	70.0	%	10 uM	24 h	-	-	293GT	CN111051298A	PGDB_A027062	PGDB_C008705	PGDB_AS002112	View
% Degradation	-	=	0.14	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A044526	PGDB_C008705	PGDB_AS000906	View
EC50	-	=	0.013	uM	-	—	IKZF2	-	-	JP2026020265A	PGDB_A051452	PGDB_C008705	PGDB_AS001524	View
EC50	-	=	0.007	uM	-	—	SALL4	-	HEK293	JP2026020265A	PGDB_A056432	PGDB_C008705	PGDB_AS001573	View
EC50	-	>	50.0	uM	-	—	-	-	293GT	CN111051298A	PGDB_A056468	PGDB_C008705	PGDB_AS002316	View
EC50	-	>	50.0	uM	-	—	-	-	293GT	CN111051298A	PGDB_A066272	PGDB_C008705	PGDB_AS000334	View
EC50	-	>	50	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A068176	PGDB_C008705	PGDB_AS002086	View

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