PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1cscc1C1CCN(Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1

Compound summary

Compound IDPGDB_C019229

FormulaC24H27N3O3S

Molecular weight437.565

InChIKeyXFWGGCQQBDBGHT-UHFFFAOYSA-N

Physicochemical properties

Exact mass437.1773

RDKit cLogP3.2

TPSA69.7

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms31

Hetero atoms7

Rings / aromatic5 / 2

Fraction Csp30.46

Formal charge0

Fragments1

Activity compounds and values

Activity records

13 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A007210	PGDB_C019229	PGDB_AS000700	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A019999	PGDB_C019229	PGDB_AS001647	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A029951	PGDB_C019229	PGDB_AS001897	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A031335	PGDB_C019229	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A032880	PGDB_C019229	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A037645	PGDB_C019229	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A037946	PGDB_C019229	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A037957	PGDB_C019229	PGDB_AS000593	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A045453	PGDB_C019229	PGDB_AS000262	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A046411	PGDB_C019229	PGDB_AS000690	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A053670	PGDB_C019229	PGDB_AS000537	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A065755	PGDB_C019229	PGDB_AS001084	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A072058	PGDB_C019229	PGDB_AS001975	View

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