PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1cccc(N2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)n1

Compound summary

Compound IDPGDB_C019235

FormulaC24H27N5O3

Molecular weight433.512

InChIKeyKDUDZSGNFPXOTO-UHFFFAOYSA-N

Physicochemical properties

Exact mass433.2114

RDKit cLogP1.47

TPSA85.8

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms32

Hetero atoms8

Rings / aromatic5 / 2

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

13 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	10-50	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A013829	PGDB_C019235	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A015640	PGDB_C019235	PGDB_AS001647	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A016601	PGDB_C019235	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A019538	PGDB_C019235	PGDB_AS000593	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A020076	PGDB_C019235	PGDB_AS001084	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A037117	PGDB_C019235	PGDB_AS001897	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A040422	PGDB_C019235	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A040729	PGDB_C019235	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A049742	PGDB_C019235	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A054637	PGDB_C019235	PGDB_AS000700	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A057182	PGDB_C019235	PGDB_AS000690	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A069429	PGDB_C019235	PGDB_AS000262	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A071153	PGDB_C019235	PGDB_AS001760	View

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