PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCN(c5cc(Cl)c(Cl)cn5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019238

FormulaC23H23Cl2N5O3

Molecular weight488.375

InChIKeyAEXVMYGERJPPMA-UHFFFAOYSA-N

Physicochemical properties

Exact mass487.1178

RDKit cLogP2.47

TPSA85.8

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms33

Hetero atoms10

Rings / aromatic5 / 2

Fraction Csp30.39

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	50-100	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A011534	PGDB_C019238	PGDB_AS001975	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A016716	PGDB_C019238	PGDB_AS001897	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A017940	PGDB_C019238	PGDB_AS000262	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A028993	PGDB_C019238	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A031316	PGDB_C019238	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A049292	PGDB_C019238	PGDB_AS002547	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A052203	PGDB_C019238	PGDB_AS000690	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A056617	PGDB_C019238	PGDB_AS001084	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A062668	PGDB_C019238	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A066306	PGDB_C019238	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A075927	PGDB_C019238	PGDB_AS000700	View

Rows per pagePage 1 of 1 · 11 recordsGo to page