PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCN(c5cccs5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019247

FormulaC22H24N4O3S

Molecular weight424.526

InChIKeyHYDXQINLZRPVNA-UHFFFAOYSA-N

Physicochemical properties

Exact mass424.1569

RDKit cLogP1.83

TPSA73

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms30

Hetero atoms8

Rings / aromatic5 / 2

Fraction Csp30.41

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A010599	PGDB_C019247	PGDB_AS001760	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A015853	PGDB_C019247	PGDB_AS000690	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A024982	PGDB_C019247	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A035681	PGDB_C019247	PGDB_AS000700	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A051580	PGDB_C019247	PGDB_AS000262	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A054330	PGDB_C019247	PGDB_AS001897	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A064364	PGDB_C019247	PGDB_AS001084	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A065983	PGDB_C019247	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A068943	PGDB_C019247	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A074212	PGDB_C019247	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A075988	PGDB_C019247	PGDB_AS002465	View

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