PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCC(c5cccc(F)c5Cl)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019254

FormulaC25H25ClFN3O3

Molecular weight469.944

InChIKeyURJASJKQGPGZJL-UHFFFAOYSA-N

Physicochemical properties

Exact mass469.1568

RDKit cLogP3.62

TPSA69.7

HBD / HBA1 / 4

Rotatable bonds4

Heavy atoms33

Hetero atoms8

Rings / aromatic5 / 2

Fraction Csp30.4

Formal charge0

Fragments1

Activity compounds and values

Activity records

13 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	1-5	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A010839	PGDB_C019254	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A014650	PGDB_C019254	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A018485	PGDB_C019254	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A021034	PGDB_C019254	PGDB_AS000700	View
IC50	-	=	1-1.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A023709	PGDB_C019254	PGDB_AS001897	View
IC50	-	<	1	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A024289	PGDB_C019254	PGDB_AS001975	View
IC50	-	<	1	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A024941	PGDB_C019254	PGDB_AS000262	View
IC50	-	<	1	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A034768	PGDB_C019254	PGDB_AS000690	View
IC50	-	<	1	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A046197	PGDB_C019254	PGDB_AS001084	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A048040	PGDB_C019254	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A060840	PGDB_C019254	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A075667	PGDB_C019254	PGDB_AS002465	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A076359	PGDB_C019254	PGDB_AS000537	View

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