PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(c2c(Cl)cc(CNC(=O)C3(c4ccc(F)cc4)CCOCC3)cc2Cl)C(=O)N1

Compound summary

Compound IDPGDB_C020315

FormulaC24H23Cl2FN2O4

Molecular weight493.362

InChIKeyVRDCLMRUNPSEAE-UHFFFAOYSA-N

Physicochemical properties

Exact mass492.1019

RDKit cLogP4.02

TPSA84.5

HBD / HBA2 / 4

Rotatable bonds5

Heavy atoms33

Hetero atoms9

Rings / aromatic4 / 2

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
EC50	-	<=	100	nM	-	—	-	-	-	KR20260041885A	PGDB_A009378	PGDB_C020315	PGDB_AS000595	View
Dmax	-	>	75	%	Concentration context: various concentrations	24 h	-	-	CAL-51	KR20260041885A	PGDB_A010154	PGDB_C020315	PGDB_AS000078	View
DC50	-	=	3	nM	-	—	NEK7	-	CAL-51	WO2025024521A1	PGDB_A024059	PGDB_C020315	PGDB_AS001365	View
EC50	-	=	100-1000	nM	-	—	CRBN	CRBN	-	WO2025024521A1	PGDB_A028733	PGDB_C020315	PGDB_AS000488	View
DC50	-	<=	100	nM	-	—	-	-	CAL-51	KR20260041885A	PGDB_A036289	PGDB_C020315	PGDB_AS000761	View
Dmax	-	>	75	%	-	-	NEK7	CRBN	-	WO2025024521A1	PGDB_A037407	PGDB_C020315	PGDB_AS002165	View
Dmax	-	=	94	%	Concentration series: 1 uM, 0.05 nM	24 h	NEK7	-	CAL-51	WO2025024521A1	PGDB_A043050	PGDB_C020315	PGDB_AS002061	View
EC50	-	=	0.05	uM	-	—	CRBN	CRBN	-	WO2025024521A1	PGDB_A048247	PGDB_C020315	PGDB_AS001033	View
Dmax	-	=	86	%	Concentration series: 1 uM, 0.05 nM	24 h	NEK7	-	CAL-51	WO2025024521A1	PGDB_A053458	PGDB_C020315	PGDB_AS002061	View
DC50	-	=	43	nM	-	—	NEK7	-	CAL-51	WO2025024521A1	PGDB_A058020	PGDB_C020315	PGDB_AS001365	View
EC50	-	=	0.49	uM	-	—	CRBN	CRBN	-	WO2025024521A1	PGDB_A076324	PGDB_C020315	PGDB_AS001033	View
DC50	-	<	100	nM	-	—	NEK7	CRBN	-	WO2025024521A1	PGDB_A077547	PGDB_C020315	PGDB_AS000280	View

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