Loading compound
Loading detail record from the SQLite release...
Compound
PGDB_C020354
10 activity records2 related patents
2D structure
CC(C)(C(=O)NCc1cc(Cl)c(C2CCC(=O)NC2=O)c(Cl)c1)c1ncc(C(F)F)cn1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 0.00196 | uM | - | — | - | - | monocyte-derived macrophages | WO2025024521A1 | PGDB_A007366 | PGDB_C020354 | PGDB_AS000832 | View |
| Dmax | - | = | 93 | % | Concentration series: 1 uM, 0.05 nM | 24 h | NEK7 | - | CAL-51 | WO2025024521A1 | PGDB_A012636 | PGDB_C020354 | PGDB_AS002061 | View |
| DC50 | - | <= | 100 | nM | - | — | - | - | CAL-51 | KR20260041885A | PGDB_A021659 | PGDB_C020354 | PGDB_AS000761 | View |
| EC50 | - | = | 100-1000 | nM | - | — | CRBN | CRBN | - | WO2025024521A1 | PGDB_A032940 | PGDB_C020354 | PGDB_AS000488 | View |
| IC50 | - | = | 0.00195 | uM | - | — | - | - | monocyte-derived macrophages | WO2025024521A1 | PGDB_A038146 | PGDB_C020354 | PGDB_AS001704 | View |
| DC50 | - | < | 100 | nM | - | — | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A039599 | PGDB_C020354 | PGDB_AS000280 | View |
| EC50 | - | = | 0.19 | uM | - | — | CRBN | CRBN | - | WO2025024521A1 | PGDB_A043067 | PGDB_C020354 | PGDB_AS001033 | View |
| DC50 | - | = | 5 | nM | - | — | NEK7 | - | CAL-51 | WO2025024521A1 | PGDB_A046708 | PGDB_C020354 | PGDB_AS001365 | View |
| Dmax | - | > | 75 | % | - | - | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A060516 | PGDB_C020354 | PGDB_AS002165 | View |
| Dmax | - | > | 75 | % | Concentration context: various concentrations | 24 h | - | - | CAL-51 | KR20260041885A | PGDB_A063284 | PGDB_C020354 | PGDB_AS000078 | View |