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Compound
PGDB_C020412
8 activity records2 related patents
2D structure
Cc1nc(CNC(=O)C(C)(C)c2ccccc2)cc(Cl)c1C1CCC(=O)NC1=OCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EC50 | - | = | 100-1000 | nM | - | — | CRBN | CRBN | - | WO2025024521A1 | PGDB_A008769 | PGDB_C020412 | PGDB_AS000488 | View |
| Dmax | - | = | 47 | % | Concentration series: 1 uM, 0.05 nM | 24 h | NEK7 | - | CAL-51 | WO2025024521A1 | PGDB_A017039 | PGDB_C020412 | PGDB_AS002061 | View |
| EC50 | - | = | 0.66 | uM | - | — | CRBN | CRBN | - | WO2025024521A1 | PGDB_A021794 | PGDB_C020412 | PGDB_AS001033 | View |
| DC50 | - | = | 100-1000 | nM | - | — | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A026434 | PGDB_C020412 | PGDB_AS000280 | View |
| Dmax | - | < | 50 | % | - | - | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A030592 | PGDB_C020412 | PGDB_AS002165 | View |
| DC50 | - | > | 1000 | nM | - | — | - | - | CAL-51 | KR20260041885A | PGDB_A042063 | PGDB_C020412 | PGDB_AS000761 | View |
| Dmax | - | > | 50 | % | Concentration context: various concentrations | 24 h | - | - | CAL-51 | KR20260041885A | PGDB_A058534 | PGDB_C020412 | PGDB_AS000078 | View |
| DC50 | - | = | 909 | nM | - | — | NEK7 | - | CAL-51 | WO2025024521A1 | PGDB_A072936 | PGDB_C020412 | PGDB_AS001365 | View |