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Compound
PGDB_C020429
9 activity records2 related patents
2D structure
COc1cnc(C(C)(C)C(=O)NCc2cc(F)c(C3CCC(=O)NC3=O)c(Cl)c2)nc1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EC50 | - | = | 0.08 | uM | - | — | CRBN | CRBN | - | WO2025024521A1 | PGDB_A009164 | PGDB_C020429 | PGDB_AS001033 | View |
| DC50 | - | = | 11 | nM | - | — | NEK7 | - | CAL-51 | WO2025024521A1 | PGDB_A011535 | PGDB_C020429 | PGDB_AS001365 | View |
| Dmax | - | > | 75 | % | - | - | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A026957 | PGDB_C020429 | PGDB_AS002165 | View |
| DC50 | - | <= | 100 | nM | - | — | - | - | CAL-51 | KR20260041885A | PGDB_A044248 | PGDB_C020429 | PGDB_AS000761 | View |
| Dmax | - | = | 85 | % | Concentration series: 1 uM, 0.05 nM | 24 h | NEK7 | - | CAL-51 | WO2025024521A1 | PGDB_A045743 | PGDB_C020429 | PGDB_AS002061 | View |
| EC50 | - | <= | 100 | nM | - | — | - | - | - | KR20260041885A | PGDB_A061970 | PGDB_C020429 | PGDB_AS000595 | View |
| EC50 | - | < | 100 | nM | - | — | CRBN | CRBN | - | WO2025024521A1 | PGDB_A068069 | PGDB_C020429 | PGDB_AS000488 | View |
| DC50 | - | < | 100 | nM | - | — | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A068890 | PGDB_C020429 | PGDB_AS000280 | View |
| Dmax | - | > | 75 | % | Concentration context: various concentrations | 24 h | - | - | CAL-51 | KR20260041885A | PGDB_A076639 | PGDB_C020429 | PGDB_AS000078 | View |