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Compound
PGDB_C021277
6 activity records1 related patents
2D structure
Cc1nc(N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5[C@H]4CCC(=O)NC4=O)cc3)CC2)cc(-n2cc(C(F)(F)F)nn2)n1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 0.01 | nM | - | — | - | - | NCI-H929 | CA3286762A1 | PGDB_A009349 | PGDB_C021277 | PGDB_AS001402 | View |
| Dmax | - | = | 74.1 | % | Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM | 24 h | IKZF1 | - | NCI-H929 | CA3286762A1 | PGDB_A017888 | PGDB_C021277 | PGDB_AS000833 | View |
| IC50 | - | = | 27 | nM | - | — | CRBN | CRBN | - | CA3286762A1 | PGDB_A030040 | PGDB_C021277 | PGDB_AS001113 | View |
| DC50 | - | = | 0.093 | nM | - | — | IKZF3 | - | NCI-H929 | CA3286762A1 | PGDB_A056752 | PGDB_C021277 | PGDB_AS000521 | View |
| DC50 | - | = | 0.37 | nM | - | — | IKZF1 | - | NCI-H929 | CA3286762A1 | PGDB_A067353 | PGDB_C021277 | PGDB_AS002338 | View |
| Dmax | - | = | 73.2 | % | Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM | 24 h | IKZF3 | - | NCI-H929 | CA3286762A1 | PGDB_A070777 | PGDB_C021277 | PGDB_AS001097 | View |