PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(NN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024192

FormulaC30H26ClN5O5

Molecular weight572.021

InChIKeySGMTWHICBZBTSZ-UHFFFAOYSA-N

Physicochemical properties

Exact mass571.1622

RDKit cLogP3.19

TPSA119.1

HBD / HBA2 / 7

Rotatable bonds5

Heavy atoms41

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.23

Formal charge0

Fragments1

Activity compounds and values

Activity records

21 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A009264	PGDB_C024192	PGDB_AS000091	View
% Inhibition	-	=	20-30	%	10 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A011836	PGDB_C024192	PGDB_AS000859	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A016495	PGDB_C024192	PGDB_AS001561	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A019135	PGDB_C024192	PGDB_AS000750	View
% Inhibition	-	=	0-10	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A023152	PGDB_C024192	PGDB_AS001140	View
IC50	-	>	10	nM	-	—	-	-	MM.1S	WO2025162225A1	PGDB_A027670	PGDB_C024192	PGDB_AS001456	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A041474	PGDB_C024192	PGDB_AS000245	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A041788	PGDB_C024192	PGDB_AS002453	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A043465	PGDB_C024192	PGDB_AS001812	View
IC50	-	>	100	nM	-	—	-	-	TMD8	WO2025162225A1	PGDB_A047022	PGDB_C024192	PGDB_AS000863	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A049470	PGDB_C024192	PGDB_AS000866	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A051587	PGDB_C024192	PGDB_AS001726	View
IC50	-	>	50	nM	-	—	-	-	RPMI-8226	WO2025162225A1	PGDB_A052509	PGDB_C024192	PGDB_AS000547	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A053279	PGDB_C024192	PGDB_AS000857	View
% Inhibition	-	=	20-30	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A054042	PGDB_C024192	PGDB_AS001155	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A058626	PGDB_C024192	PGDB_AS002558	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A059627	PGDB_C024192	PGDB_AS000568	View
% Inhibition	-	=	10-20	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A064353	PGDB_C024192	PGDB_AS001349	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A068004	PGDB_C024192	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A069281	PGDB_C024192	PGDB_AS000689	View

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