PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CCC(C4)N5C(=O)c4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024211

FormulaC32H30ClN5O4

Molecular weight584.076

InChIKeyYKOIGUFTOJUKRC-UHFFFAOYSA-N

Physicochemical properties

Exact mass583.1986

RDKit cLogP4.08

TPSA102.1

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms42

Hetero atoms10

Rings / aromatic7 / 3

Fraction Csp30.31

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A007461	PGDB_C024211	PGDB_AS002540	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A020805	PGDB_C024211	PGDB_AS002558	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A023724	PGDB_C024211	PGDB_AS001812	View
% Inhibition	-	=	80-100	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A037064	PGDB_C024211	PGDB_AS001155	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A038464	PGDB_C024211	PGDB_AS002133	View
% Inhibition	-	=	80-100	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A048033	PGDB_C024211	PGDB_AS001349	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A052064	PGDB_C024211	PGDB_AS000160	View
% Inhibition	-	=	80-100	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A061074	PGDB_C024211	PGDB_AS001140	View
% Inhibition	-	=	100-105	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A061336	PGDB_C024211	PGDB_AS001561	View
% Inhibition	-	=	80-100	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A063048	PGDB_C024211	PGDB_AS000245	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A063425	PGDB_C024211	PGDB_AS000568	View
% Inhibition	-	=	100-105	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A064581	PGDB_C024211	PGDB_AS000857	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A067262	PGDB_C024211	PGDB_AS000866	View
% Inhibition	-	=	80-100	%	10 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A073273	PGDB_C024211	PGDB_AS000859	View

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