PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CCC(C4)N5C(c4cccc(F)c4)c4cccc(F)c4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024229

FormulaC32H31F2N5O3

Molecular weight571.628

InChIKeyVKAMIUPYXNTMGN-UHFFFAOYSA-N

Physicochemical properties

Exact mass571.2395

RDKit cLogP3.99

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms42

Hetero atoms10

Rings / aromatic7 / 3

Fraction Csp30.34

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	20-30	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A008534	PGDB_C024229	PGDB_AS000866	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A009016	PGDB_C024229	PGDB_AS001140	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A009955	PGDB_C024229	PGDB_AS001726	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A016433	PGDB_C024229	PGDB_AS000857	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A022362	PGDB_C024229	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A023843	PGDB_C024229	PGDB_AS000689	View
% Inhibition	-	=	70-80	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A024166	PGDB_C024229	PGDB_AS001349	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A027086	PGDB_C024229	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A044665	PGDB_C024229	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A063076	PGDB_C024229	PGDB_AS000091	View
% Inhibition	-	=	70-80	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A063176	PGDB_C024229	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A069269	PGDB_C024229	PGDB_AS000351	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A070587	PGDB_C024229	PGDB_AS000568	View
% Inhibition	-	=	60-70	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A071027	PGDB_C024229	PGDB_AS000245	View

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