PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CCC(C4)N5C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024230

FormulaC32H31Cl2N5O3

Molecular weight604.538

InChIKeyATEHGZLYDJLMCA-UHFFFAOYSA-N

Physicochemical properties

Exact mass603.1804

RDKit cLogP5.02

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms42

Hetero atoms10

Rings / aromatic7 / 3

Fraction Csp30.34

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A007126	PGDB_C024230	PGDB_AS000857	View
% Inhibition	-	=	60-70	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A012491	PGDB_C024230	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A014575	PGDB_C024230	PGDB_AS000689	View
% Inhibition	-	=	70-80	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A018250	PGDB_C024230	PGDB_AS001349	View
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A040845	PGDB_C024230	PGDB_AS000245	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A046647	PGDB_C024230	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A047053	PGDB_C024230	PGDB_AS000091	View
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A054065	PGDB_C024230	PGDB_AS001140	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A057551	PGDB_C024230	PGDB_AS000866	View
% Inhibition	-	=	30-40	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A058148	PGDB_C024230	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A073364	PGDB_C024230	PGDB_AS000351	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A073510	PGDB_C024230	PGDB_AS000568	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A074461	PGDB_C024230	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A075824	PGDB_C024230	PGDB_AS000750	View

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