PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN117756818A

AssigneeBeijing Hospital

TitleA kind of glutarimide compound and its preparation method and application

Family ID90321263

Family members2

Filing year2023

Publication date2024-03-26

JurisdictionCN

Compounds22

Activity records154

Assays7

Activity compounds and values

Activity records

154 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	100-1000	nM	-	—	BRD4/GSPT1	-	HL-60	PGDB_A007022	PGDB_C000361	PGDB_AS001357	View
% Degradation	-	=	90-100	%	-	-	-	-	MOLM-13	PGDB_A007713	PGDB_C000368	PGDB_AS002573	View
% Degradation	-	=	90-100	%	-	-	-	-	MOLM-13	PGDB_A007770	PGDB_C000376	PGDB_AS002573	View
IC50	-	<	100	nM	-	—	BRD4/GSPT1	-	HL-60	PGDB_A008239	PGDB_C000368	PGDB_AS001357	View
% Degradation	-	=	90-100	%	-	-	-	-	MOLM-13	PGDB_A008645	PGDB_C000374	PGDB_AS002573	View
% Degradation	-	=	50-70	%	-	-	-	-	MOLM-13	PGDB_A008676	PGDB_C000378	PGDB_AS000622	View
IC50	-	=	100-1000	nM	-	—	-	-	MOLM-13	PGDB_A008746	PGDB_C000378	PGDB_AS001583	View
% Degradation	-	<	30	%	-	-	-	-	MOLM-13	PGDB_A009491	PGDB_C000377	PGDB_AS002573	View
IC50	-	=	100-1000	nM	-	—	-	-	THP-1	PGDB_A011829	PGDB_C000363	PGDB_AS000638	View
IC50	-	=	100-1000	nM	-	—	BRD4/GSPT1	-	Oci-AML3	PGDB_A012063	PGDB_C000361	PGDB_AS002081	View
IC50	-	<	100	nM	-	—	BRD4/GSPT1	-	Oci-AML3	PGDB_A012688	PGDB_C000365	PGDB_AS002081	View
IC50	-	<	100	nM	-	—	BRD4/GSPT1	-	Oci-AML3	PGDB_A013614	PGDB_C000366	PGDB_AS002081	View
IC50	-	<	100	nM	-	—	-	-	THP-1	PGDB_A014202	PGDB_C000365	PGDB_AS000638	View
IC50	-	<	100	nM	-	—	BRD4/GSPT1	-	HL-60	PGDB_A014248	PGDB_C000376	PGDB_AS001357	View
IC50	-	=	77.32	nM	-	—	-	-	MOLM-13	PGDB_A014263	PGDB_C000364	PGDB_AS001583	View
% Degradation	-	=	70-90	%	-	-	-	-	MOLM-13	PGDB_A014306	PGDB_C000366	PGDB_AS000622	View
IC50	-	=	100-1000	nM	-	—	-	-	MOLM-13	PGDB_A014440	PGDB_C000360	PGDB_AS001583	View
% Degradation	-	=	70-90	%	-	-	-	-	MOLM-13	PGDB_A014456	PGDB_C000363	PGDB_AS002573	View
IC50	-	=	100-1000	nM	-	—	-	-	THP-1	PGDB_A015433	PGDB_C000360	PGDB_AS000638	View
IC50	-	<	100	nM	-	—	BRD4/GSPT1	-	NB4	PGDB_A015573	PGDB_C000360	PGDB_AS000935	View

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