PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025090727A1

AssigneeMonte Rosa Therapeutics

TitleCompounds that mediate protein degradation and methods of use thereof

Family ID93563120

Family members1

Filing year2024

Publication date2025-05-01

JurisdictionWO

Compounds8

Activity records24

Assays3

Activity compounds and values

Activity records

24 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	=	67.6	%	-	24 h	CDK2	-	HEK293	PGDB_A007852	PGDB_C010135	PGDB_AS002016	View
DC50	-	=	166.7	nM	-	—	CDK2	-	HEK293	PGDB_A010409	PGDB_C010141	PGDB_AS001688	View
Dmax	-	=	63.5	%	-	24 h	CDK2	-	HEK293	PGDB_A010417	PGDB_C010138	PGDB_AS002016	View
Dmax	-	=	0.4	%	-	24 h	GSPT1	-	HEK293	PGDB_A010610	PGDB_C010134	PGDB_AS001842	View
DC50	-	=	46.5	nM	-	—	CDK2	-	HEK293	PGDB_A013211	PGDB_C010139	PGDB_AS001688	View
Dmax	-	=	4.8	%	-	24 h	GSPT1	-	HEK293	PGDB_A015455	PGDB_C010137	PGDB_AS001842	View
Dmax	-	=	6.9	%	-	24 h	GSPT1	-	HEK293	PGDB_A015797	PGDB_C010141	PGDB_AS001842	View
Dmax	-	=	62.2	%	-	24 h	CDK2	-	HEK293	PGDB_A019081	PGDB_C010140	PGDB_AS002016	View
Dmax	-	=	3.7	%	-	24 h	GSPT1	-	HEK293	PGDB_A019328	PGDB_C010140	PGDB_AS001842	View
Dmax	-	=	62.6	%	-	24 h	CDK2	-	HEK293	PGDB_A027516	PGDB_C010141	PGDB_AS002016	View
Dmax	-	=	9.9	%	-	24 h	GSPT1	-	HEK293	PGDB_A032781	PGDB_C010139	PGDB_AS001842	View
DC50	-	=	97.4	nM	-	—	CDK2	-	HEK293	PGDB_A032827	PGDB_C010135	PGDB_AS001688	View
Dmax	-	=	47.5	%	-	24 h	CDK2	-	HEK293	PGDB_A037103	PGDB_C010134	PGDB_AS002016	View
Dmax	-	=	19.6	%	-	24 h	GSPT1	-	HEK293	PGDB_A044198	PGDB_C010138	PGDB_AS001842	View
Dmax	-	=	18.8	%	-	24 h	GSPT1	-	HEK293	PGDB_A045200	PGDB_C010135	PGDB_AS001842	View
Dmax	-	=	62	%	-	24 h	CDK2	-	HEK293	PGDB_A048059	PGDB_C010139	PGDB_AS002016	View
DC50	-	=	181.5	nM	-	—	CDK2	-	HEK293	PGDB_A048086	PGDB_C010138	PGDB_AS001688	View
DC50	-	=	27	nM	-	—	CDK2	-	HEK293	PGDB_A048309	PGDB_C010140	PGDB_AS001688	View
DC50	-	=	785.1	nM	-	—	CDK2	-	HEK293	PGDB_A051372	PGDB_C010134	PGDB_AS001688	View
Dmax	-	=	11.2	%	-	24 h	GSPT1	-	HEK293	PGDB_A052840	PGDB_C010136	PGDB_AS001842	View

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