PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(O[C@H]4CCCC[C@@H]4N4CC(c5ccccc5)C4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000466

FormulaC28H31N3O4

Molecular weight473.573

InChIKeyDQYZQRGRHXEYPT-PFIFLBKHSA-N

Physicochemical properties

Exact mass473.2315

RDKit cLogP3.24

TPSA79

HBD / HBA1 / 5

Rotatable bonds5

Heavy atoms35

Hetero atoms7

Rings / aromatic6 / 2

Fraction Csp30.46

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	CN117836288A	PGDB_A014258	PGDB_C000466	PGDB_AS001378	View
% Degradation	-	=	77.9	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A018984	PGDB_C000466	PGDB_AS002458	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	US20230265071A1	PGDB_A024731	PGDB_C000466	PGDB_AS000322	View
EC50	-	=	0.004	uM	-	—	CRBN	CRBN	-	US20230265071A1	PGDB_A027243	PGDB_C000466	PGDB_AS001482	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	CN117836288A	PGDB_A030034	PGDB_C000466	PGDB_AS001378	View
EC50	-	=	0.004	uM	-	—	CRBN	CRBN	HEK293T	CN117836288A	PGDB_A044756	PGDB_C000466	PGDB_AS001696	View
EC50	-	=	0.004	uM	-	—	CRBN	CRBN	HEK293T	CN117836288A	PGDB_A044841	PGDB_C000466	PGDB_AS001696	View
EC50	-	=	0.004	uM	-	—	IKZF2	CRBN	HEK293T	AR126418A1	PGDB_A046477	PGDB_C000466	PGDB_AS001328	View
% Degradation	-	=	77.9	%	1 uM	24 h	IKZF2	CRBN	HEK293T	AR126418A1	PGDB_A046874	PGDB_C000466	PGDB_AS000416	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	US20230265071A1	PGDB_A059261	PGDB_C000466	PGDB_AS000322	View
% Degradation	-	=	77.9	%	1 uM	24 h	IKZF2	-	HEK293T	US20230265071A1	PGDB_A060940	PGDB_C000466	PGDB_AS000278	View
EC50	-	=	0.004	uM	-	—	CRBN	CRBN	-	US20230265071A1	PGDB_A063826	PGDB_C000466	PGDB_AS001482	View
% Degradation	-	=	84.8	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A067492	PGDB_C000466	PGDB_AS002458	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	AR126418A1	PGDB_A068455	PGDB_C000466	PGDB_AS002212	View
% Degradation	-	=	84.8	%	1 uM	24 h	IKZF2	-	HEK293T	US20230265071A1	PGDB_A074499	PGDB_C000466	PGDB_AS000278	View

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