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Compound
PGDB_C006592
7 activity records1 related patents
2D structure
Cc1cccc2nc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CC5)cnn34)cn12Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 1.5 | nM | - | — | CDK12 | - | A673 | CN114929708B | PGDB_A019117 | PGDB_C006592 | PGDB_AS002202 | View |
| IC50 | - | = | 36 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A028881 | PGDB_C006592 | PGDB_AS001066 | View |
| IC50 | - | = | 334 | nM | - | — | CDK7 | - | - | CN114929708B | PGDB_A032524 | PGDB_C006592 | PGDB_AS002150 | View |
| Selectivity index | CDK7 / CDK12 | = | 9.3 | fold | - | — | - | - | - | CN114929708B | PGDB_A034221 | PGDB_C006592 | PGDB_AS002236 | View |
| IC50 | - | = | 36 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A044211 | PGDB_C006592 | PGDB_AS001268 | View |
| IC50 | - | = | 36 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A061377 | PGDB_C006592 | PGDB_AS001187 | View |
| IC50 | - | = | 1.5 | nM | - | — | CDK12 | - | A673 | CN114929708B | PGDB_A069863 | PGDB_C006592 | PGDB_AS002570 | View |