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Compound
PGDB_C011633
11 activity records1 related patents
2D structure
CCn1c(-c2cc(C#CCN3CCS(=O)(=O)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H]1C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | > | 1000 | nM | - | — | BRAF | - | A375 | WO2025214350A1 | PGDB_A009173 | PGDB_C011633 | PGDB_AS001949 | View |
| IC50 | - | <= | 1 | nM | - | — | KRAS | - | SW620 | WO2025214350A1 | PGDB_A013860 | PGDB_C011633 | PGDB_AS001156 | View |
| IC50 | - | = | 0.328 | nM | - | — | KRAS | - | AGS | WO2025214350A1 | PGDB_A030635 | PGDB_C011633 | PGDB_AS000075 | View |
| IC50 | - | <= | 1 | nM | - | — | KRAS | - | NCI-H358 | WO2025214350A1 | PGDB_A032522 | PGDB_C011633 | PGDB_AS001442 | View |
| IC50 | - | = | 1.043 | nM | - | — | KRAS | - | HPAC | WO2025214350A1 | PGDB_A032553 | PGDB_C011633 | PGDB_AS000104 | View |
| IC50 | - | <= | 1 | nM | - | — | - | - | AsPC-1 | WO2025214350A1 | PGDB_A037564 | PGDB_C011633 | PGDB_AS001410 | View |
| IC50 | - | <= | 1 | nM | - | — | KRAS | - | AGS | WO2025214350A1 | PGDB_A044910 | PGDB_C011633 | PGDB_AS000218 | View |
| IC50 | - | = | 0.6982 | nM | - | — | KRAS | - | NCI-H358 | WO2025214350A1 | PGDB_A045157 | PGDB_C011633 | PGDB_AS000944 | View |
| IC50 | - | = | 0.1535 | nM | - | — | KRAS | - | SW620 | WO2025214350A1 | PGDB_A054568 | PGDB_C011633 | PGDB_AS000800 | View |
| IC50 | - | = | 0.8654 | nM | - | — | KRAS | - | AsPC-1 | WO2025214350A1 | PGDB_A067998 | PGDB_C011633 | PGDB_AS001593 | View |
| IC50 | - | = | 1-10 | nM | - | — | KRAS | - | HPAC | WO2025214350A1 | PGDB_A070993 | PGDB_C011633 | PGDB_AS002124 | View |