PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC(C)(C(=O)NCc1cc(Cl)c(C2CCC(=O)NC2=O)c(Cl)c1)c1ccc(C2CC2)nn1

Compound summary

Compound IDPGDB_C020365

FormulaC23H24Cl2N4O3

Molecular weight475.376

InChIKeyQNNGFOKAAJMETQ-UHFFFAOYSA-N

Physicochemical properties

Exact mass474.1225

RDKit cLogP3.77

TPSA101

HBD / HBA2 / 5

Rotatable bonds6

Heavy atoms32

Hetero atoms9

Rings / aromatic4 / 2

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	92	%	Concentration series: 1 uM, 0.05 nM	24 h	NEK7	-	CAL-51	WO2025024521A1	PGDB_A009276	PGDB_C020365	PGDB_AS002061	View
Dmax	-	>	75	%	Concentration context: various concentrations	24 h	-	-	CAL-51	KR20260041885A	PGDB_A011350	PGDB_C020365	PGDB_AS000078	View
EC50	-	<=	100	nM	-	—	-	-	-	KR20260041885A	PGDB_A017612	PGDB_C020365	PGDB_AS000595	View
Dmax	-	>	75	%	-	-	NEK7	CRBN	-	WO2025024521A1	PGDB_A022949	PGDB_C020365	PGDB_AS002165	View
EC50	-	=	0.09	uM	-	—	CRBN	CRBN	-	WO2025024521A1	PGDB_A026329	PGDB_C020365	PGDB_AS001033	View
DC50	-	=	5	nM	-	—	NEK7	-	CAL-51	WO2025024521A1	PGDB_A033642	PGDB_C020365	PGDB_AS001365	View
DC50	-	<	100	nM	-	—	NEK7	CRBN	-	WO2025024521A1	PGDB_A041942	PGDB_C020365	PGDB_AS000280	View
IC50	-	=	0.00094	uM	-	—	-	-	monocyte-derived macrophages	WO2025024521A1	PGDB_A043339	PGDB_C020365	PGDB_AS000832	View
DC50	-	<=	100	nM	-	—	-	-	CAL-51	KR20260041885A	PGDB_A047484	PGDB_C020365	PGDB_AS000761	View
EC50	-	<	100	nM	-	—	CRBN	CRBN	-	WO2025024521A1	PGDB_A060295	PGDB_C020365	PGDB_AS000488	View
IC50	-	=	0.00075	uM	-	—	-	-	monocyte-derived macrophages	WO2025024521A1	PGDB_A067117	PGDB_C020365	PGDB_AS001704	View

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