PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CC4CN5C(c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024244

FormulaC31H31N5O3

Molecular weight521.621

InChIKeyWUPUAWDFRSBLSS-UHFFFAOYSA-N

Physicochemical properties

Exact mass521.2427

RDKit cLogP3.32

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms39

Hetero atoms8

Rings / aromatic7 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

18 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A008025	PGDB_C024244	PGDB_AS001942	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A008914	PGDB_C024244	PGDB_AS002484	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A010604	PGDB_C024244	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A020066	PGDB_C024244	PGDB_AS000689	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A022675	PGDB_C024244	PGDB_AS002540	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A027995	PGDB_C024244	PGDB_AS000568	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A032669	PGDB_C024244	PGDB_AS000091	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A034631	PGDB_C024244	PGDB_AS001349	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A039341	PGDB_C024244	PGDB_AS001561	View
% Inhibition	-	=	53-60	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A042670	PGDB_C024244	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A043444	PGDB_C024244	PGDB_AS000750	View
% Inhibition	-	=	70-80	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A053944	PGDB_C024244	PGDB_AS001155	View
% Inhibition	-	=	20-30	%	10 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A054784	PGDB_C024244	PGDB_AS000160	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A057858	PGDB_C024244	PGDB_AS002558	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A059040	PGDB_C024244	PGDB_AS001140	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A060766	PGDB_C024244	PGDB_AS000866	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A061903	PGDB_C024244	PGDB_AS001726	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A076191	PGDB_C024244	PGDB_AS000351	View

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