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Compound
PGDB_C000395
10 activity records3 related patents
2D structure
O=C1CCC(N2Cc3c(ccc(O[C@H]4CCCC[C@@H]4N4CC(c5ccccc5)C4)c3Cl)C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | < | 15 | % | 1 uM | 24 h | IKZF2 | - | HEK293T | US20230265071A1 | PGDB_A014022 | PGDB_C000395 | PGDB_AS000278 | View |
| EC50 | - | = | 0.061 | uM | - | — | CRBN | CRBN | HEK293T | CN117836288A | PGDB_A016937 | PGDB_C000395 | PGDB_AS001696 | View |
| EC50 | - | = | 0.043 | uM | - | — | CRBN | CRBN | HEK293T | CN117836288A | PGDB_A018183 | PGDB_C000395 | PGDB_AS001696 | View |
| EC50 | - | = | 0.043 | uM | - | — | CRBN | CRBN | - | US20230265071A1 | PGDB_A021531 | PGDB_C000395 | PGDB_AS001482 | View |
| EC50 | - | = | 0.061 | uM | - | — | IKZF2 | CRBN | HEK293T | AR126418A1 | PGDB_A030093 | PGDB_C000395 | PGDB_AS001328 | View |
| % Degradation | - | < | 15 | % | 1 uM | 24 h | IKZF2 | CRBN | HEK293T | CN117836288A | PGDB_A040006 | PGDB_C000395 | PGDB_AS002458 | View |
| % Degradation | - | < | 15 | % | 1 uM | 24 h | IKZF2 | - | HEK293T | US20230265071A1 | PGDB_A042277 | PGDB_C000395 | PGDB_AS000278 | View |
| EC50 | - | = | 0.061 | uM | - | — | CRBN | CRBN | - | US20230265071A1 | PGDB_A055590 | PGDB_C000395 | PGDB_AS001482 | View |
| % Degradation | - | < | 15 | % | 1 uM | 24 h | IKZF2 | CRBN | HEK293T | CN117836288A | PGDB_A059241 | PGDB_C000395 | PGDB_AS002458 | View |
| % Degradation | - | < | 15 | % | 1 uM | 24 h | IKZF2 | CRBN | HEK293T | AR126418A1 | PGDB_A074183 | PGDB_C000395 | PGDB_AS000416 | View |