PatGlueDB | Molecular Glue Patent Bioactivity Database

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2D structure

2D structure for PGDB_C001301

O=C1CCC(N2Cc3cc(C(=O)c4ccccc4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001301

FormulaC20H16N2O4

Molecular weight348.358

InChIKeyZDHUXJPMJJXHCH-UHFFFAOYSA-N

Physicochemical properties

Exact mass348.111

RDKit cLogP1.68

TPSA83.5

HBD / HBA1 / 4

Rotatable bonds3

Heavy atoms26

Hetero atoms6

Rings / aromatic4 / 2

Fraction Csp30.2

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

Structure		Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
	GI50	-	=	0.1-1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A012204	PGDB_C001301	PGDB_AS000013	View
	% Degradation	-	=	70-90	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A014952	PGDB_C001301	PGDB_AS001448	View
	% Degradation	-	=	30-50	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A027617	PGDB_C001301	PGDB_AS002288	View
	GI50	-	=	0.1-1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A033430	PGDB_C001301	PGDB_AS001887	View
	% Degradation	-	=	70-90	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A037177	PGDB_C001301	PGDB_AS001994	View
	% Degradation	-	=	50-70	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A053374	PGDB_C001301	PGDB_AS001008	View
	Relative binding	Ctrl @ 5uM	<	10	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A054824	PGDB_C001301	PGDB_AS001966	View
	Relative binding	Ctrl @ 5uM	<	10	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A064218	PGDB_C001301	PGDB_AS000026	View
	% Degradation	-	=	30-50	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A064229	PGDB_C001301	PGDB_AS001067	View
	% Degradation	-	=	50-70	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A077106	PGDB_C001301	PGDB_AS000601	View

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