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Patent
WO2025110699A1
60 compounds269 activity records7 assays
Patent summary
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | % Degradation | - | = | 90-100 | % | 10 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A007052 | PGDB_C001322 | PGDB_AS001994 | View |
 | % Degradation | - | = | 70-90 | % | 0.1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A007081 | PGDB_C001336 | PGDB_AS001067 | View |
 | % Degradation | - | = | 70-90 | % | 10 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A007788 | PGDB_C001345 | PGDB_AS001994 | View |
 | % Degradation | - | = | 90-100 | % | 0.1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A008236 | PGDB_C001302 | PGDB_AS001067 | View |
 | GI50 | - | = | 0.1-1 | uM | - | — | GSPT1 | - | Jurkat | PGDB_A008601 | PGDB_C001312 | PGDB_AS001887 | View |
 | % Degradation | - | = | 30-50 | % | 0.1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A008778 | PGDB_C001329 | PGDB_AS001067 | View |
 | % Degradation | - | = | 50-70 | % | 1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A009275 | PGDB_C001317 | PGDB_AS001008 | View |
 | GI50 | - | <= | 0.1 | uM | - | — | GSPT1 | - | MM.1S | PGDB_A009373 | PGDB_C001327 | PGDB_AS002497 | View |
 | % Degradation | - | = | 90-100 | % | 10 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A009427 | PGDB_C001330 | PGDB_AS001994 | View |
 | GI50 | - | = | 0.1-1 | uM | - | — | GSPT1 | - | Jurkat | PGDB_A010010 | PGDB_C001348 | PGDB_AS001887 | View |
| % Degradation | - | = | 70-90 | % | 1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A010367 | PGDB_C001336 | PGDB_AS001008 | View |
 | GI50 | - | <= | 0.1 | uM | - | — | GSPT1 | - | Jurkat | PGDB_A010463 | PGDB_C001326 | PGDB_AS001887 | View |
 | % Degradation | - | = | 50-70 | % | 0.1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A010634 | PGDB_C001340 | PGDB_AS001067 | View |
 | Relative binding | Ctrl @ 5uM | < | 1 | % | 5 uM | 1 h | CRBN | CRBN | HEK293 | PGDB_A011004 | PGDB_C001303 | PGDB_AS001966 | View |
 | Relative binding | Ctrl @ 5uM | < | 0.1 | % | 5 uM | 1 h | CRBN | CRBN | HEK293 | PGDB_A011063 | PGDB_C001314 | PGDB_AS001966 | View |
 | GI50 | - | <= | 0.1 | uM | - | — | GSPT1 | - | MM.1S | PGDB_A011311 | PGDB_C001325 | PGDB_AS002497 | View |
 | % Degradation | - | = | 90-100 | % | 1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A011384 | PGDB_C001349 | PGDB_AS001008 | View |
 | % Degradation | - | = | 70-90 | % | 1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A011460 | PGDB_C001344 | PGDB_AS001008 | View |
 | % Degradation | - | = | 90-100 | % | 1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A011515 | PGDB_C001321 | PGDB_AS001008 | View |
| % Degradation | - | = | 90-100 | % | 1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A012657 | PGDB_C001348 | PGDB_AS001008 | View |