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Patent
KR20250075510A
60 compounds237 activity records5 assays
Patent summary
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | % Degradation | - | = | 90-100 | % | 10 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A007119 | PGDB_C001340 | PGDB_AS001448 | View |
 | Relative binding | Ctrl @ 5uM | < | 0.1 | % | 5 uM | 1 h | CRBN | CRBN | HEK-293 | PGDB_A007466 | PGDB_C001322 | PGDB_AS000026 | View |
 | Relative binding | Ctrl @ 5uM | < | 0.1 | % | 5 uM | 1 h | CRBN | CRBN | HEK-293 | PGDB_A007582 | PGDB_C001312 | PGDB_AS000026 | View |
 | % Degradation | - | = | 90-100 | % | 10 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A007973 | PGDB_C001324 | PGDB_AS001448 | View |
 | Relative binding | Ctrl @ 5uM | < | 0.1 | % | 5 uM | 1 h | CRBN | CRBN | HEK-293 | PGDB_A008318 | PGDB_C001323 | PGDB_AS000026 | View |
 | % Degradation | - | = | 70-90 | % | 0.1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A008470 | PGDB_C001313 | PGDB_AS002288 | View |
 | % Degradation | - | = | 70-90 | % | 0.1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A008905 | PGDB_C001343 | PGDB_AS002288 | View |
 | GI50 | - | <= | 0.1 | nM | - | — | GSPT1 | - | Jurkat | PGDB_A009494 | PGDB_C001302 | PGDB_AS000013 | View |
 | GI50 | - | = | 1-10 | nM | - | — | GSPT1 | - | Jurkat | PGDB_A009531 | PGDB_C001334 | PGDB_AS000013 | View |
 | % Degradation | - | = | 70-90 | % | 0.1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A009661 | PGDB_C001351 | PGDB_AS002288 | View |
 | % Degradation | - | = | 90-100 | % | 1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A009940 | PGDB_C001347 | PGDB_AS000601 | View |
 | % Degradation | - | = | 30-50 | % | 0.1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A010299 | PGDB_C001338 | PGDB_AS002288 | View |
 | % Degradation | - | = | 70-90 | % | 1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A010469 | PGDB_C001305 | PGDB_AS000601 | View |
 | GI50 | - | <= | 0.1 | nM | - | — | GSPT1 | - | Jurkat | PGDB_A010647 | PGDB_C001314 | PGDB_AS000013 | View |
 | % Degradation | - | = | 70-90 | % | 0.1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A011451 | PGDB_C001349 | PGDB_AS002288 | View |
 | % Degradation | - | = | 90-100 | % | 1 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A012132 | PGDB_C001330 | PGDB_AS000601 | View |
 | GI50 | - | = | 0.1-1 | nM | - | — | GSPT1 | - | Jurkat | PGDB_A012204 | PGDB_C001301 | PGDB_AS000013 | View |
| % Degradation | - | = | 50-70 | % | 10 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A013345 | PGDB_C001338 | PGDB_AS001448 | View |
 | % Degradation | - | = | 90-100 | % | 10 uM | 24 h | GSPT1 | - | Jurkat | PGDB_A013942 | PGDB_C001318 | PGDB_AS001448 | View |
| Relative binding | Ctrl @ 5uM | < | 0.1 | % | 5 uM | 1 h | CRBN | CRBN | HEK-293 | PGDB_A014164 | PGDB_C001302 | PGDB_AS000026 | View |