PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)c4cc5ccccc5[nH]4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001302

FormulaC22H17N3O4

Molecular weight387.395

InChIKeyGNOIKTKZJUXZIV-UHFFFAOYSA-N

Physicochemical properties

Exact mass387.1219

RDKit cLogP2.16

TPSA99.3

HBD / HBA2 / 4

Rotatable bonds3

Heavy atoms29

Hetero atoms7

Rings / aromatic5 / 3

Fraction Csp30.18

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	90-100	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A008236	PGDB_C001302	PGDB_AS001067	View
GI50	-	<=	0.1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A009494	PGDB_C001302	PGDB_AS000013	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A014164	PGDB_C001302	PGDB_AS000026	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A014239	PGDB_C001302	PGDB_AS001008	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A025593	PGDB_C001302	PGDB_AS001994	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MV-4-11	WO2025110699A1	PGDB_A049269	PGDB_C001302	PGDB_AS002004	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A050054	PGDB_C001302	PGDB_AS001887	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A050988	PGDB_C001302	PGDB_AS001966	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MM.1S	WO2025110699A1	PGDB_A055333	PGDB_C001302	PGDB_AS002497	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A068876	PGDB_C001302	PGDB_AS000601	View
% Degradation	-	=	90-100	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A068915	PGDB_C001302	PGDB_AS002288	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A071967	PGDB_C001302	PGDB_AS001448	View

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