PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(C(=O)c4cc5ccccc5[nH]4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001307

FormulaC22H15N3O5

Molecular weight401.378

InChIKeyKDLAJXOBNLNZHH-UHFFFAOYSA-N

Physicochemical properties

Exact mass401.1012

RDKit cLogP1.8

TPSA116.4

HBD / HBA2 / 5

Rotatable bonds3

Heavy atoms30

Hetero atoms8

Rings / aromatic5 / 3

Fraction Csp30.14

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
GI50	-	=	1-10	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A015738	PGDB_C001307	PGDB_AS001887	View
GI50	-	=	1-10	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A023840	PGDB_C001307	PGDB_AS000013	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A025834	PGDB_C001307	PGDB_AS001994	View
% Degradation	-	=	50-70	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A042141	PGDB_C001307	PGDB_AS001008	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A048750	PGDB_C001307	PGDB_AS001448	View
% Degradation	-	=	50-70	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A056614	PGDB_C001307	PGDB_AS000601	View
% Degradation	-	=	30-50	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A058076	PGDB_C001307	PGDB_AS002288	View
Relative binding	Ctrl @ 5uM	<	10	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A059744	PGDB_C001307	PGDB_AS001966	View
Relative binding	Ctrl @ 5uM	<	10	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A073556	PGDB_C001307	PGDB_AS000026	View
% Degradation	-	=	30-50	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A073919	PGDB_C001307	PGDB_AS001067	View

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